Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Article Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Beta Blood caused clinically Concentration coronavirus COVID-19 creatine phosphokinase CT-P63 deaths declining Delta demonstrated detectable dose double-blind evaluated groups healthy volunteer Immunity in vitro in vivo Infection Infectious virus lung monoclonal monoclonal antibody morbidity and mortality mutated variant Neutralizing Neutralizing activity neutralizing antibody neutralizing antibody. omicron pandemic parallel-group participant peaked phase Placebo placebo-controlled Preclinical prevalent Prophylactic Randomized reduced respiratory tract Safe SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants of concern Serious Adverse Events significantly single ascending dose study drug TEAE titre Tolerability Transgenic mouse treated Treatment treatment-emergent adverse event vaccination variants variants of SARS-CoV-2 wild-type [DOI] 10.1080/22221751.2022.2117094 PMC 바로가기
Production of single-cycle infectious SARS-CoV-2 through a trans-complemented repliconArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome approach BAC Cell cells clone coated Coronavirus-2 COVID-19 culture supernatant did not produce elicit expression generate IFN immune response infected cell Infection Infectious virus Live attenuated vaccine memory N protein nucleocapsid omicron overexpression plaques platform Production progeny provide Replication replicon rescued resulting RNA robust S protein SARS-CoV-2 single-cycle infectious virus. Strains transient expression transmission electron microscopy type I interferon Vaccine Viral RNA virion virus [DOI] 10.1002/jmv.28057 PMC 바로가기
Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomesArticle Published on 2022-11-042022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] administration airway analysed association Asymptomatic atraumatic biodistribution cardiovascular systems Cell consequence cynomolgus macaque cynomolgus macaques Disrupted exhibit exhibited hamster Host host susceptibility hosts identify Infection Infectious virus intranasal Lower respiratory tract lung Lung pathology methodology Microscopy Mild molecular morphology New World NHP non-human primate organelle outcome outcomes Pathogenesis pathological outcome pathology pathophysiological Post-infection Replication representing SARS-CoV-2 SARS-COV-2 infection susceptible ultrastructure Virological virus virus particle [DOI] 10.1038/s41598-022-23339-x PMC 바로가기
SARS-CoV-2 quasi-species analysis from patients with persistent nasopharyngeal sheddingArticle Published on 2022-11-042022-11-16 Journal: Scientific Reports [Category] SARS, 변종, [키워드] Analysis asked both groups clade Consequences Control COVID 19 deviation Evolution of SARS-CoV-2 genomic greater Human immune system immune evasion increase Infectious virus Interaction intra-individual investigated Mutation N501Y nasopharyngeal no significant difference P681H pandemic Patient patients performed persistence Prevent question RNA virus SARS-CoV-2 Sequencing Standard survival the SARS-CoV-2 therapeutic two group Variability variants viral propagation viral variant [DOI] 10.1038/s41598-022-22060-z PMC 바로가기
Low Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission by Fomites: A Clinical Observational Study in Highly Infectious Coronavirus Disease 2019 PatientsArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] acute respiratory syndrome addressed baseline carrier Cell culture clinical coronavirus 2 coronavirus disease Coronavirus-2 coughing COVID-19 COVID-19 patient Culture Cycle threshold value evaluate fomite transmission Hospitalized Infectious virus initiated Intensive laboratory parameter occur oropharyngeal swab pandemic Patient polymerase chain positive Quantitative respiratory risk Saliva SARS-CoV-2 SARS-CoV-2 transmission Sequencing single-center stability surface stability. Swab Transmission unlikely Viral load viral ribonucleic acid virus virus transmission [DOI] 10.1093/infdis/jiac170 PMC 바로가기
A subunit vaccine candidate based on the Spike protein of SARS-CoV-2 prevents infectious virus shedding in catsSARS-CoV-2의 스파이크 단백질을 기반으로 하는 서브유닛 백신 후보는 고양이의 감염성 바이러스 발산을 방지합니다Article Published on 2022-11-012022-09-11 Journal: Research in veterinary science [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected cats demonstrated described effective human infection Infection Infectious virus Neutralizing antibody response occurred Oropharyngeal Population Prevent preventive measure preventive measures produced Protein rectal swab SARS-CoV-2 SARS-CoV-2 virus spike Spike protein submitted subunit Subunit vaccine Subunit vaccine. susceptible the disease the SARS-CoV-2 virus the Spike Transmission Trial triggered vaccination Vaccine vaccine candidate Viral viral infection virus [DOI] 10.1016/j.rvsc.2022.05.003 PMC 바로가기 [Article Type] Article
Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort studyArticle Published on 2022-11-012022-11-15 Journal: The Lancet. Respiratory Medicine [Category] SARS, 변종, 치료기술, [키워드] accelerate Alpha assessment assumption Bayesian Cohort cohort study Community Contact correlation Course COVID-19 COVID-19 case determine diagnosed early diagnosis eight eligible enrolled Evidence Final Guidance Hierarchical High-resolution household index cases Infection infection control Infectious virus initial IQR Isolation kinetic Lateral flow device LFD median Older Onset participant PCR positive PCR-confirmed plaque-forming unit post-symptom onset Probability quantified real-world data recruitment reduced released RT-PCR SARS-CoV-2 Self-isolation sensitivity Seven study population suggested Support survival Symptom symptom onset Symptoms the median the SARS-CoV-2 to define Transmission upper respiratory tract variant viral growth Viral load viral replication Viral RNA viral RNA load viral shedding virus were assessed [DOI] 10.1016/S2213-2600(22)00226-0 PMC 바로가기
Infection and Transmission of SARS-CoV-2 B.1.617.2 Lineage (Delta Variant) among Fully Vaccinated IndividualsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Alpha variant analysis Asia association B.1.1.7 lineage B.1.617.2 Breakthrough infection breakthrough infection. circulating Cluster Complete conducted coronavirus disease COVID-19 Delta delta variant demonstrated determine diagnostic dominant epidemiologically evaluate Evidence Factor genomic genotyping highest increase in independent individual individuals Infection Infectious virus information Isolation Lineage New York PCR peaked performed phylogenetic clusters positive real-time reverse transcriptase Replication SARS-CoV-2 SARS-CoV-2 lineage secretion sequence spread to subset Surveillance the SARS-CoV-2 Transmission transmission clusters transmission of SARS-CoV-2 vaccinated individual vaccinated individuals vaccination rate Viral load viral RNA load viral titer virological assessment virus Virus titration VoC [DOI] 10.1128/spectrum.00563-22 PMC 바로가기
Point-of-care detection of SARS-CoV-2 antigen among symptomatic vs. asymptomatic persons: Testing for COVID-19 vs. infectivityArticle Published on 2022-10-172022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome Ag-RDT Antigen Asymptomatic Buenos Aires Care caused Concordance Contact coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient detect diagnose diagnostic evaluate false-negative hypothetical identify individual Infectious virus Isolation pandemic Participants PCR point-of-care positive public health qRT-PCR rapid antigen testing real-time RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 testing subjects Surveillance symptomatic t -value Testing threshold Transmission utility viral kinetics viral kinetics. was obtained [DOI] 10.3389/fpubh.2022.995249 PMC 바로가기
No infectious SARS-CoV-2 in breast milk from a cohort of 110 lactating womenArticle Published on 2022-10-012022-11-15 Journal: Pediatric Research [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition analyzed Breast breast milk Breastfeeding breastmilk Cohort coronavirus Culture detectable diagnostic diagnostic tests Evidence examined experiments freeze-thaw cycles human milk Infants Infection Infectious virus lactating women marker occur positive recent remained risk factor RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral RNA sgRNA Symptom symptomatic tested Transmission viral culture virus vRNA women [DOI] 10.1038/s41390-021-01902-y PMC 바로가기